What is Addison's Disease?
When the adrenal cortex is harmed and the adrenal glands don't produce enough cortisol and aldosterone, Addison's disease develops. One adrenal gland is located on top of each kidney and is triangular in shape, measuring around three inches (7.6 cm) by one inch (2.5 cm) in size. Three different forms of hormone are produced by the cortex, the outer portion of the adrenal gland:
Glucocorticoids (particularly cortisol) (especially cortisol)
Mineralocorticoids (particularly aldosterone) (especially aldosterone)
Steroids for s*x (or androgens)
History
Addison’s disease is named after Thomas Addison, the British physician who first described the condition in on the Constitutional and Local Effects of Disease of the Suprarenal Capsules (1855). All of Addison’s six original patients had tuberculosis of the adrenal glands. While Addison’s six patients in 1855 all had adrenal tuberculosis, the term “Addison’s disease” does not imply an underlying disease process.
The condition was initially considered a form of anemia associated with the adrenal glands. Because little was known at the time about the adrenal glands (then called “Supra-Renal Capsules”), Addison’s monograph describing the condition was an isolated insight. As the adrenal function became better known, Addison’s monograph became known as an important medical contribution and a classic example of careful medical observation.
Epidemiology of Addison’s disease
Addison’s disease affects males and females in equal numbers. Approximately 1 in 100,000 people in United States have Addison’s disease. The overall prevalence is estimated to be between 40 and 60 people per million of the general population. Because cases of Addison’s disease may go undiagnosed, it is difficult to determine its true frequency in the general population. Addison’s disease can potentially affect individuals of any age, but usually occurs in individuals between 30-50 years of age.
Risk factors
Injury of adrenal gland
Autoimmune Disease
Steroid Therapy
Tuberculosis of adrenal glands
Operation on adrenal gland
Amyloid Disease
Sepsis
anticoagulants
Use of certain medications
Genetic Predisposition to Disease
Primary Hypercoagulable State
Addison’s disease causes
By far the most common cause of Addison’s disease is autoimmunity. This is known as autoimmune Addison’s disease. Normally the body’s immune system attacks invading viruses and bacteria to defend the body. In cases of autoimmunity, the immune system makes a mistake, attacking and destroying the adrenal cortex as if it was an infection.
Rare causes of Addison’s disease include infections such as tuberculosis, removal of the adrenal glands by surgery, bleeding into the adrenal glands (for instance after abdominal injuries), cancer of the adrenal glands and genetic defects such as adrenoleukodystrophy.
The pituitary gland produces hormones that affect the adrenal gland. If the pituitary gland stops working properly, this can cause secondary adrenal insufficiency.
Symptoms
Addison’s disease symptoms usually develop slowly, often over several months, and may include:
Extreme fatigue
Weight loss and decreased appetite
Darkening of your skin (hyperpigmentation)
Low blood pressure, even fainting
Salt craving
Low blood sugar (hypoglycemia)
Nausea, diarrhea or vomiting
Abdominal pain
Muscle or joint pains
Irritability
Depression
Body hair loss or sexual dysfunction in women
Complications of Addison’s disease
Shock
Death
Low Blood Pressure
Decreased vascular resistance
Diagnosis and test
Your doctor may undergo some of the following tests:
Blood test: Measuring your blood levels of sodium, potassium, cortisol, and ACTH gives your doctor an initial indication of whether adrenal insufficiency may be causing your signs and symptoms. A blood test can also measure antibodies associated with autoimmune Addison’s disease.
ACTH stimulation test: This test involves measuring the level of cortisol in your blood before and after an injection of synthetic ACTH. ACTH signals your adrenal glands to produce cortisol. If your adrenal glands are damaged, the ACTH stimulation test shows that your output of cortisol in response to synthetic ACTH is limited or nonexistent.
Insulin-induced hypoglycemia test: Occasionally, doctors suggest this test if pituitary disease is a possible cause of adrenal insufficiency (secondary adrenal insufficiency). The test involves checking your blood sugar (blood glucose) and cortisol levels at various intervals after an injection of insulin. In healthy people, glucose levels fall and cortisol levels increase.
Imaging tests: Your doctor may have you undergo a computerized tomography (CT) scan of your abdomen to check the size of your adrenal glands and look for other abnormalities that may give insight to the cause of the adrenal insufficiency. Your doctor may also suggest an MRI scan of your pituitary gland if testing indicates you might have secondary adrenal insufficiency.
Treatment and medications
Your treatment will depend on what is causing your condition. Your doctor may prescribe medications that regulate the adrenal gland.
Following the treatment plan that your doctor creates for you is very important. Untreated Addison’s disease can lead to an Addisonian crisis.
If your condition has gone untreated for too long, and has progressed to a life-threatening condition called Addisonian crisis, your physician may prescribe medication to treat that first. Addisonian crisis causes low blood pressure, high potassium in the blood, and low blood sugar levels.
Medications
To enhance your health, you might need to take a combination of glucocorticoids (drugs that reduce inflammation). You must take these medications consistently for the rest of your life, never skipping a dosage.
If your adrenal glands are not producing enough hormones, a hormone replacement may be administered.
Stopping Addison's disease
The treatment of Addison's symptoms and averting an Addisonian crisis, which is brought on by extremely stressful situations, are the primary goals of prevention. Treating underlying disorders and reducing risk factors, such as autoimmune diseases, may help to prevent this sickness.
The following danger signs could shield against Addison's disease:
Taking care of fungus diseases.
Regulating diabetes.
Recognize cancer symptoms to stop the spread of cells to the bloodstream and adrenal glands.
Stress management and soothing hobbies can help people with Addison's disease avoid serious symptoms and problems.
Share with your love ones and enjoy your day. Thank you.